Goals before the break from Spinazzola and Rrahmani delivered a win for the visitors at the Stadio Olimpico in a fixture marred by multiple sendings-off.
The win propels Conte's side to just one point behind of Serie A leaders Milan, who won on Friday. Inter Milan hold third place but have a chance to go back to the top with a win in their later match.
Control Despite Absences
Hampered by the absence of a number of key personnel, the southern Italian side commanded the game with patient build-up play. The first goal came when Politano's delivery was drilled home by Spinazzola at the back post.
The lead was doubled in the first half as the defender guided a glancing header from another Politano set-piece into the bottom corner. Napoli went close to a third shortly after when Eljif Elmas saw his header crash against the woodwork.
Tempers Flare and Red Cards
After the break saw further injury concern for the away side when a player limped off. This incident sparked a brief confrontation, resulting in bookings for Rrahmani and the home side's Noslin—who then received a second yellow for a foul.
"I must congratulate my players, playing with this level of quality and physical strength while preventing Lazio have control is not easy," remarked the winning head coach. "We played at a very high level of play."
Tempers boiled over again late on as two opponents were embroiled in a fierce confrontation, prompting the coach to intervene. The two players were shown red cards for their involvement in the clash.
Other European Fixtures
In Spain's La Liga, Sevilla suffered a heavy loss at home to struggling the Granotas. Levante established a lead with a well-worked move before adding two more strikes in the second period to seal a comprehensive victory.
In other news, Los Blancos host significant pressure when they play Real Betis, after their arch-rivals extended their lead at the summit. In the day's late game, Atlético Madrid travel to face Real Sociedad.
In France, a historic Parisian clasico is scheduled as the newly-promoted side face powerhouses Paris Saint-Germain. This match represents the inaugural top-flight meeting between the two clubs in decades, adding extra spice to the weekend's action.
